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Same Diet, Different Results?

New research shows genetic differences influence how individuals' cholesterol levels respond to low-carb diets, particularly related to saturated fat intake.

Same Diet, Different Results?
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Have you ever wondered why two people can follow the exact same low-carb diet and end up with completely different health results? New research presented by the American Society for Nutrition points to a simple explanation: your genes.

  1. Genetic Sensitivity: People genetically predisposed to high cholesterol experience a much sharper increase in bad cholesterol (LDL) when switching to a low-carbohydrate diet compared to those without the genetic tendency.
  2. The Role of Saturated Fat: High saturated fat intake interacts directly with genetic risk, driving up LDL levels on low-carb diets. This link was not seen in participants following a low-fat diet.
  3. Polygenic Scoring: Researchers analyzed thousands of genetic variants to build a polygenic score, which helps explain why two people on the exact same low-carb regimen can have completely different cholesterol responses.
  4. Practical Dietary Advice: Even without genetic testing, individuals on low-carb diets can protect their cardiovascular health by swapping saturated fats (like butter and fatty meats) for unsaturated sources like nuts, seeds, olive oil, and avocados.


Source: Science Daily

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